Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults
Glutamate release is a root cause of acute and delayed neuronal damage in response to hypoxic/ischemic insults.Nevertheless, therapeutics that target the postsynaptic compartment have been read more disappointing clinically.Here we explored whether presynaptic silencing (muting) of glutamatergic terminals is sufficient to reduce excitotoxic damage